GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2275426 | 1 | rs4376778 | chr1:46288846 | MMACHC | chr1:45965856-45976737:+ | -0.19 | -4.28 | 2.28E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs4376778 | chr1:46288846 | MUTYH | chr1:45794915-45806142:- | 0.31 | 8.34 | 7.97E-16 | Body mass index |
| THCA | cis | rs6988636 | 1 | rs4377946 | chr8:124185887 | FAM83A | chr8:124191287-124222317:+ | -0.34 | -4.19 | 3.33E-5 | Urinary uromodulin levels |
| THCA | cis | rs2243480 | 1 | rs437889 | chr7:65509234 | CCT6P1 | chr7:65216092-65228661:+ | 0.4 | 6.39 | 3.94E-10 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs437889 | chr7:65509234 | CRCP | chr7:65579805-65619551:+ | -0.28 | -4.27 | 2.41E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs437889 | chr7:65509234 | RABGEF1 | chr7:66093890-66276446:+ | 0.57 | 7.14 | 3.48E-12 | Diabetic kidney disease |
| THCA | cis | rs738322 | 1 | rs4379 | chr22:38569171 | PLA2G6 | chr22:38507502-38577836:- | 0.09 | 3.35 | 0.000879 | Cutaneous nevi |
| THCA | cis | rs7923609 | 1 | rs4379723 | chr10:64963449 | NRBF2 | chr10:64893007-64914785:+ | -0.29 | -6.95 | 1.22E-11 | Educational attainment;Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs438034 | 1 | rs438034 | chr1:214830617 | KCNK2 | chr1:215178885-215410435:+ | 0.17 | 3.57 | 0.000397 | Response to antineoplastic agents |
| THCA | cis | rs738322 | 1 | rs4381 | chr22:38570791 | PLA2G6 | chr22:38507502-38577836:- | 0.1 | 3.67 | 0.000273 | Cutaneous nevi |
| THCA | cis | rs738322 | 1 | rs4382 | chr22:38570842 | PLA2G6 | chr22:38507502-38577836:- | 0.1 | 3.67 | 0.000273 | Cutaneous nevi |
| THCA | cis | rs7735563 | 1 | rs4385200 | chr5:130487658 | HINT1 | chr5:130494875-130501034:- | -0.25 | -3.5 | 0.000516 | Diisocyanate-induced asthma |
| THCA | cis | rs1605070 | 1 | rs4387956 | chr3:51915619 | RAD54L2 | chr3:51575596-51697610:+ | 0.08 | 3.68 | 0.000257 | Amyotrophic lateral sclerosis (sporadic) |
| THCA | cis | rs12196860 | 1 | rs4388288 | chr6:55948205 | COL21A1 | chr6:55921389-56258892:- | -0.66 | -8.1 | 4.59E-15 | Psychosis (atypical) |
| THCA | cis | rs344081 | 1 | rs439295 | chr3:156572455 | LEKR1 | chr3:156544076-156763918:+ | -0.56 | -11.28 | 2.62E-26 | Bone mineral density |